If you only use New Outlook in the Chrome browser, we recommend that you install your email signature using our Chrome Extension.
If you need to use New Outlook on both Windows or macOS and also in the Chrome browser, you will need to use our Add-In instead.
Visit the Chrome Web Store to add the extension to your Chrome Browser.

Open the Email Signature Rescue extension by clicking on the pink ESR logo at the top right of your Chrome browser.
Note: If you don't see the ESR icon, click the Extensions icon then click the pin next to the Email Signature Rescue extension.
Click the Add New Email Signature button to create an install. Select Outlook from the email client dropdown list, then paste your signature key into the next field and click Save Key.
Important: If you're using more than one email account, click Advanced Settings then enter the email address of the account that you want your email signature to work with. This will prevent the signature from being applied to all email accounts.

Compose a new email and your email signature will automatically insert when sending emails from Outlook 365 for web in Chrome.